Thoughts on SGM – phage therapy

This week’s post is by Lauren Cowley, a PhD student in our lab studying the phage typing of E. coli O157. She was at SGM in Manchester last week and kindly agreed to write a blog post on one of the topics which made an impression on her; phage therapy…   Having just returned from…

A bacteriophage encodes it’s own CRISPR

Just thought I would just do a quick post on a really interesting paper, ‘A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity’. Briefly summarised below… Vibrio cholera is in a dynamic relationship with phage – walking a tight rope between increasing phage resistance and decreasing virulence. There is an evolutionary…

Hello world!

Hello! This blog is going to have a three main aspects: Interesting bioinformatics titbits e.g. what is the impact of k-mer correction (e.g. Musket) compared to quality filtering in terms of mapping and assembly statistics. Preliminary results from our project – the use of whole genome sequencing for typing of E. coli O157:H7. Noteworthy papers…