Given I was only looking for a single column of data (Postcode mapped to Constituency), I actually could still get it to work in Excel. It makes the file 35Mb in size just with the 2.5mil rows of two columns (actually three sets of two columns with a little under a million rows in each of the three) and the VLOOKUP then just does =IFERROR(VLOOKUP[on list one],IFERROR(VLOOKUP([on list two],VLOOKUP([on list three]))), which does actually work and still just about opens and saves on my (newish and goodish but not top-of-the-range) laptop with Excel 2013.

But yes, that’s not really ‘analyse it’ so you’re right, adding much more than that would probably kill Excel ðŸ˜‰

]]>– RaxML uses fixed branch lengths across partitions (not 100% sure RaxML doesn’t have this option now, a while ago it didn’t), Iqtree allows completely unlinked, or proportional, or unfixed model. The proportional model is more recommended than equal branch lengths across partitions (ratios among brlens in a partition are kept the same in another except for a constant of proportionality), because it accommodates more properly partitions having different rates.

– UFBoot support in Iqtree has a much better correlation with probability of clade being correct than regular bootstrap (but not known compared to previously known support measures).

– Iqtree permits using (by the way, even testing) molecular models, while RaxML is stright GTR (plus with or w/o rate heterogeneity).

– Iqtree has better flexibility at defining mixture models (can be important for minimizing compositional biases).

– Iqtree permits the use of heterotachy models. It’s probably the 1st software to allow for different lineages having different rates across partitions that is fast for large phylogenomic datasets.

I may be forgetting something… in any case, it’s definitely worth testing.

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